insulin + glucose (University of Missouri)

The hyperinsulinemic-euglycemic infusion, commonly known as the 'clamp' technique, is a clinical procedure used to measure insulin sensitivity and metabolic response. In the context of research at the University of Missouri-Columbia, this intervention is utilized as a mechanistic tool to study the physiological effects of insulin in individuals with obesity, specifically focusing on its role in modulating blood flow and sympathetic nervous system activity. The procedure involves the simultaneous intravenous administration of insulin to raise systemic insulin levels (hyperinsulinemia) and glucose (dextrose) at a variable rate to maintain normal blood sugar levels (euglycemia). By titrating the glucose infusion rate to match the rate of insulin-stimulated glucose uptake, researchers can quantify the degree of insulin resistance. This specific study (NCT01142635) also investigated how these responses are influenced by endothelin-1 (ET-1) signaling.

Other names

Hyperinsulinemic, euglycemic infusionHyperinsulinemic-euglycemic clampInsulin-glucose infusion