Drug intelligence / Profile preview

insulin aspart + basal insulin + metformin

Development stage
Unknown
Lead developer
Novo Nordisk
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Subcutaneous, Oral
01

Overview

**insulin aspart + basal insulin + metformin** is a combination therapy for diabetes that uses three distinct drugs: - **Insulin aspart** is a rapid-acting insulin analogue for managing postprandial glucose spikes[1]. - **Basal insulin** includes long-acting insulins (such as insulin degludec, insulin glargine, insulin detemir) for background glucose control[4][2]. - **Metformin** is an oral small molecule antihyperglycemic agent (a biguanide) that decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity. The combination is primarily used for patients with type 2 diabetes who require intensive glycemic control beyond oral agent therapy alone, or sometimes in type 1 diabetes for comprehensive management. This regimen addresses both fasting and postprandial glucose, utilizing different mechanisms: stimulation of glucose uptake (insulin), reduction of hepatic production (metformin), and sustained basal coverage.

Brand names
none
Other names
insulin aspart plus basal insulin plus metformininsulin aspart and basal insulin and metformin
02

Targets

INSR (Insulin receptor)AMPK (Adenosine monophosphate–activated protein kinase)ND1 (Mitochondrial electron transport chain complex I)

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