insulin glargine + metformin

Insulin glargine + metformin is a combination therapy used primarily for the management of type 2 diabetes mellitus. Insulin glargine is a long-acting recombinant insulin analog that provides basal insulin coverage, helping to regulate blood glucose levels over approximately 24 hours by promoting glucose uptake into tissues and suppressing hepatic glucose production[1][2][4]. Metformin is an oral biguanide antihyperglycemic agent that lowers blood sugar by decreasing hepatic gluconeogenesis, reducing intestinal absorption of glucose, and increasing peripheral tissue sensitivity to insulin[5][8]. This combination targets both impaired insulin secretion (with exogenous basal insulin) and increased hepatic glucose output/insulin resistance (with metformin), providing complementary mechanisms for glycemic control in patients with type 2 diabetes who require more than one agent for optimal management.

Brand names

Lantus

Other names

insulin glargine + metformin