insulin human + insulin degludec

This drug is a **combination of human insulin and insulin degludec**. Both are peptide hormones used for managing blood glucose levels in diabetes mellitus. **Human insulin** is a recombinant form of natural human insulin, while **insulin degludec** is a long-acting insulin analog designed for prolonged glucose-lowering effect. Both lower blood glucose by promoting peripheral glucose uptake (mainly in muscle and fat), inhibiting hepatic glucose production, and suppressing lipolysis and proteolysis[1][3][4].\n\n**Mechanism of action:** Both components act as agonists at the insulin receptor. Insulin degludec additionally exhibits a delayed and prolonged absorption phase due to multihexamer formation at the injection site and reversible binding to albumin in circulation, giving it an ultra-long duration of action[1][4].\n\nThis combination is used for the **treatment of diabetes mellitus** (primarily type 1 and type 2 diabetes) in patients who require both a basal (long-acting) component and an additional insulin to mimic physiological insulin activity, or to achieve optimal glycemic control[1][3][4].