Drug intelligence / Profile preview

interferon beta + interleukin-2

Development stage
Discontinued
Modality
Cytokines & Interferons → Recombinant Proteins and Enzymes
Administration
Intravenous
01

Overview

A combination immunotherapy consisting of interferon beta (IFN-beta) and interleukin-2 (IL-2). Both are biological response modifiers that work through different but complementary immune pathways. When combined, they appear to have synergistic antitumor effects that were initially demonstrated in mouse tumor models[4]. This synergy provided the rationale for human clinical trials. The combination has been primarily investigated for renal cell carcinoma and other advanced malignancies, though clinical results have shown modest efficacy with response rates around 9-10%.

Other names
IFN-beta + IL-2
02

Targets

IFNAR (Immune system modulation via type I interferon receptor)IL-2R (Interleukin-2/interleukin-15 receptor complex)

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