Drug intelligence / Profile preview

interferon beta-1b + atorvastatin

Development stage
Unknown
Lead developer
Bayer HealthCare Pharmaceuticals
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Oral, Subcutaneous
01

Overview

This is a combination of two drugs: interferon beta-1b, a recombinant protein immunomodulator used primarily for the treatment of multiple sclerosis (MS), and atorvastatin, an oral small molecule statin used to lower cholesterol. Interferon beta-1b acts by decreasing inflammation and preventing nerve damage in MS through modulation of immune responses. Atorvastatin inhibits HMG-CoA reductase, reducing cholesterol synthesis and also exhibits anti-inflammatory and immunomodulatory properties. The combination has been studied in relapsing-remitting multiple sclerosis (RRMS) to assess whether adding atorvastatin to standard interferon beta therapy provides additional benefit; clinical trials have shown no significant improvement over monotherapy with interferon beta alone[1][2][5]. Both drugs are well-established pharmaceuticals with distinct primary indications.

Brand names
Betaferon
Other names
Interferon β-1bNVF233NVF-233NVF 233SH 579SH579SH-579ZK 157046ZK157046ZK-157046
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)IFNAR (Immune system modulation via type I interferon receptor)

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