Drug intelligence / Profile preview

intravenous immunoglobulin + prednisolone

Development stage: Unknown
Lead developer: CSL Behring
Modality: Small Molecules
Administration: Intravenous, Oral

Overview

A combination therapy consisting of intravenous immunoglobulin (IVIG) and prednisolone (a corticosteroid). This combination is used to treat various autoimmune and inflammatory conditions. The mechanism involves immunomodulation through multiple pathways - IVIG works by neutralizing circulating autoantibodies, blocking Fc receptors, inhibiting complement activation, and modulating cytokine production, while prednisolone exerts anti-inflammatory and immunosuppressive effects through inhibition of inflammatory mediators and immune cell function.

Other names: IVIG + prednisoloneIVIG + prednisoneintravenous immunoglobulin + prednisoneIVIg and corticosteroidsIVIg and systemic corticosteroids

Targets

FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)NF-κBComplement (Complement system)GR (Glucocorticoid receptor)

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