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intravenous immunoglobulin + recombinant human thrombopoietin
- Development stage
- Preclinical
- Modality
- Tissue Cells → Other Cell Types → Cell Therapies, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intravenous, Subcutaneous
01
Overview
This is a combination therapy consisting of intravenous immunoglobulin (IVIG) and recombinant human thrombopoietin (rhTPO). IVIG is a blood product containing pooled IgG antibodies from healthy donors, used primarily for its immunomodulatory effects in autoimmune and inflammatory diseases. Recombinant human thrombopoietin is a full-length glycosylated cytokine produced by Chinese hamster ovary cells that mimics endogenous thrombopoietin to stimulate the production of megakaryocytes and platelets via activation of the MPL receptor. The combination may be used in clinical settings where both immune modulation (to reduce platelet destruction) and stimulation of platelet production are desired, such as severe or refractory immune thrombocytopenia or chemotherapy-induced thrombocytopenia[1][2][5]. Both components have distinct mechanisms—IVIG modulates immune responses while rhTPO directly stimulates platelet generation.
- Other names
- IVIG + rhTPOIVIG plus recombinant human thrombopoietinintravenous immunoglobulin and rhTPO
02
Targets
TPOR (Thrombopoietin receptor)Complement component C5aFCGRT (Neonatal crystallizable fragment receptor)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)
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