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This input is not a single drug entity; it names **three distinct nonionic iodinated X-ray contrast agents**: iodixanol, ioversol, and iopromide. These injectable diagnostic agents increase radiographic contrast by attenuating X-rays within the blood vessels, cardiac chambers, urinary tract, and other perfused structures during angiography and contrast-enhanced CT. Iodixanol is a dimeric iso-osmolar agent, whereas ioversol and iopromide are low-osmolar monomeric agents. The cited GE HealthCare-sponsored clinical study compared their effects on renal function after contrast administration in patients at risk of kidney injury. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00335101))
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