iopamidol + hydrocortisone

A combination of iopamidol, a non-ionic radiographic contrast agent, and hydrocortisone, a glucocorticoid. Iopamidol is used in various imaging procedures, including angiography and CT scans, to enhance contrast by absorbing X-rays. Hydrocortisone is used to treat conditions like corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. This combination is explicitly **contraindicated for intrathecal administration** due to serious risks, including death, convulsions, cerebral hemorrhage, coma, paralysis, and other severe adverse effects. The FDA label for iopamidol includes a black box warning regarding the risks associated with its intrathecal use, and this contraindication extends to its combination with intrathecal corticosteroids like hydrocortisone.