Drug intelligence / Profile preview

irinotecan + nedaplatin

Development stage
Unknown
Lead developer
Yakult Honsha
Modality
Small Molecules
Administration
Intravenous
01

Overview

Irinotecan + nedaplatin is a chemotherapy combination regimen that has been studied for treating various types of cancer. Irinotecan is a topoisomerase I inhibitor, while nedaplatin is a platinum-based antineoplastic agent similar to cisplatin but with potentially reduced toxicity. This combination has shown efficacy in treating primary advanced and recurrent cervical cancer, advanced germ cell tumors, and clear cell carcinoma. In clinical trials, it has demonstrated response rates of up to 81% in primary advanced cervical cancer and 40% in recurrent disease, with manageable toxicity profiles.

02

Targets

DNATOP1 (DNA Topoisomerase I)

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