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irinotecan hydrochloride liposome + anlotinib + enlonstobart
- Development stage
- Unknown
- Lead developer
- CSPC Pharmaceutical Group
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Oral
01
Overview
This combination therapy is an investigational regimen consisting of irinotecan hydrochloride liposome, anlotinib, and enlonstobart. **Irinotecan hydrochloride liposome** is a liposomal formulation of the cytotoxic topoisomerase I inhibitor irinotecan, designed to provide sustained drug release and improved tumor penetration. **Anlotinib** is a multi-target small molecule tyrosine kinase inhibitor that primarily targets VEGFR1/2/3, FGFR1-4, PDGFR alpha/beta, and c-Kit, thereby inhibiting tumor angiogenesis and proliferation. **Enlonstobart** (also known as SG001) is a humanized monoclonal antibody that acts as a checkpoint inhibitor by targeting the programmed cell death protein 1 (PD-1) receptor, enhancing the immune system's anti-tumor response. The combination is being evaluated for its synergistic potential in treating advanced solid tumors, particularly colorectal cancer, by simultaneously attacking the tumor through cytotoxic, anti-angiogenic, and immunotherapeutic pathways.
- Brand names
- Duoenda
- Other names
- SG001 + AL3818 + Irinotecan Liposome
02
Targets
TOP1 (DNA Topoisomerase I)FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR4 (Vascular endothelial growth factor Receptor-3)VEGFR2 (Vascular endothelial growth factor receptor 2)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDCD1 (Programmed cell death protein 1 receptor)PDGFRB (Platelet-derived growth factor receptor beta)FGFR4 (Fibroblast growth factor receptor 4)PDGFRA (Platelet-derived growth factor receptor alpha)
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