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ISIS 14803 + peginterferon alfa + ribavirin
- Development stage
- Phase 2
- Lead developer
- Ionis Pharmaceuticals
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Molecules
- Administration
- Intravenous, Subcutaneous, Oral
01
Overview
ISIS 14803 + peginterferon alfa + ribavirin is a combination therapy investigated for the treatment of chronic hepatitis C virus (HCV) infection, particularly in patients who have not responded adequately to standard therapy with peginterferon alfa and ribavirin alone. ISIS 14803 is an experimental antisense phosphorothioate oligodeoxynucleotide that targets the translation initiation region of the HCV internal ribosome entry site (IRES), inhibiting viral protein expression by binding to viral RNA and inducing RNase H-mediated cleavage. Peginterferon alfa is a recombinant interferon that induces innate immune responses against HCV, while ribavirin is a nucleoside analog antiviral agent. The combination was studied in Phase 1/2 clinical trials to assess safety, tolerability, and antiviral activity in chronic hepatitis C patients with poor response to standard therapy[1][2][5][6].
- Other names
- peginterferon alfaribavirin
02
Targets
HCV IRES (Hepatitis C virus internal ribosome entry site)NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)IFNAR (Immune system modulation via type I interferon receptor)HCV RNA (Hepatitis C virus RNA)RdRp (Coronavirus RNA-dependent RNA polymerase)
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