Drug intelligence / Profile preview

iso-[131I]SGMIB-A345

Development stage: Preclinical
Lead developer: Duke University Medical Center
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

iso-[131I]SGMIB-A345 is a preclinical GPC3-targeted radiopharmaceutical developed by Duke University Medical Center. It consists of the GPC3-specific single-domain antibody fragment (sdAb) A345 conjugated to the radioiodinated residualizing prosthetic agent 1,3,5-[131I]SGMIB (iso-SGMIB). The agent is designed for targeted radionuclide therapy (TRT) of Glypican-3 (GPC3)-expressing malignancies, such as hepatocellular carcinoma and neuroendocrine prostate cancer. A345 can be prepared as a monomer, dimer, or trimer, with multimeric forms demonstrating enhanced binding affinity and cellular internalization in GPC3-positive tumor models.

Other names: 1,3,5-[131I]SGMIB-A345iso-[131I]SGMIB-A345-dimeriso-[131I]SGMIB-A345-monomeriso-[131I]SGMIB-A345-trimer

Targets

GPC3 (Glypican-3)

Beyond the preview

Go deeper on iso-[131I]SGMIB-A345.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on iso-[131I]SGMIB-A345.