Drug intelligence / Profile preview

isoetharine + phenylephrine

Development stage
Discontinued
Lead developer
Sterling Winthrop
Modality
Small Molecules
Administration
Inhalation, Intranasal
01

Overview

**Isoetharine + phenylephrine** is a historical fixed-dose inhaled bronchodilator combination marketed as **Bronkosol**. Isoetharine is a relatively selective short-acting beta-2 adrenergic receptor agonist that relaxes bronchial smooth muscle, while phenylephrine is an alpha-1 adrenergic receptor agonist. In controlled studies in asthma and reversible bronchospasm, the combination produced bronchodilation, although phenylephrine alone did not produce bronchodilation and its addition to isoetharine showed no clear incremental pulmonary benefit. The product is discontinued. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/323326/))

Other names
isoetharine + phenylephrineisoetharine hydrochloride + phenylephrine hydrochlorideisoetharine with phenylephrineisoetharine/phenylephrine
02

Targets

ADRA1A (α1A)ADRB2 (β2)ADRB1 (β1)

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