Drug intelligence / Profile preview

isopropyl alcohol + lidocaine hydrochloride + povidone-iodine + methylprednisolone acetate

Development stage
Approved
Lead developer
Asclemed USA
Modality
Small Molecules
Administration
Intramuscular, Intraarticular, Intralesional, Topical
01

Overview

A fixed combination drug kit containing **methylprednisolone acetate**, **lidocaine hydrochloride**, **povidone-iodine**, and **isopropyl alcohol**, marketed as a procedural injection kit for corticosteroid administration. The principal therapeutic component is methylprednisolone acetate, a depot synthetic glucocorticoid small molecule that exerts anti-inflammatory effects primarily through activation of the glucocorticoid receptor and downstream suppression of pro-inflammatory gene transcription. Lidocaine hydrochloride provides local anesthetic activity by blocking voltage-gated sodium channels, while povidone-iodine and isopropyl alcohol function as topical antiseptics for skin preparation rather than as the main therapeutic agents. Based on the provided labeling context, the kit is associated with uses aligned with injectable methylprednisolone acetate, including intramuscular, intra-articular, soft tissue, intralesional, and related short-term anti-inflammatory indications; the supplied context also notes that this labeling has not been approved by the FDA and that the product has not been found by FDA to be safe and effective.

Brand names
DYURAL L KIT
Other names
isopropyl alcohol + lidocaine hydrochloride + povidone-iodine + methylprednisolone acetatemethylprednisolone acetate + lidocaine hydrochloride + povidone-iodine + isopropyl alcohol
02

Targets

NaV (Voltage-gated sodium channels)GR (Glucocorticoid receptor)

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