Drug intelligence / Profile preview

isopropyl alcohol + menthol + calendula oil

Development stage
Unknown
Modality
Small Molecules
Administration
Topical
01

Overview

This is a **topical combination product** containing isopropyl alcohol, menthol, and calendula oil, most commonly employed as an *analgesic liniment* for external use. - **Isopropyl alcohol** acts as an antiseptic and vehicle, facilitating rapid evaporation and penetration into the skin, and can provide mild antimicrobial action. - **Menthol** is a counterirritant and provides a cooling sensation by activating transient receptor potential melastatin 8 (TRPM8) ion channels in sensory neurons, relieving localized pain through gate control mechanisms and providing mild local anesthesia. - **Calendula oil** (from Calendula officinalis) is included for its purported anti-inflammatory, soothing, and skin-healing properties, and is often used in herbal medicine to support tissue repair in minor skin injuries. This type of liniment is often compounded in pharmacies, included in OTC pain-relief sprays, or prepared as an herbal remedy for *minor aches, muscle and joint pain, or inflammation*. There is no evidence it is marketed under a unique proprietary or trade name as a combination product, but these three ingredients often appear together in multi-ingredient analgesic sprays and liniments. Mechanism of action includes local anesthetic, counterirritant, anti-inflammatory, and skin-protective effects.

02

Targets

TRPM8 (Transient receptor potential cation channel subfamily M member 8)

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