isotonic saline + hypertonic saline + ringer lactate

This combination refers to the co-administration or sequential use of isotonic saline (0.9% sodium chloride), hypertonic saline (typically 3% or 7.5% sodium chloride), and Ringer's lactate solution. These crystalloid fluids are primarily used for volume expansion, fluid resuscitation, and electrolyte replacement in clinical settings such as hemorrhagic shock, trauma, and major surgery. Isotonic saline and Ringer's lactate are standard maintenance and resuscitation fluids, while hypertonic saline is utilized to rapidly expand intravascular volume or manage intracranial pressure by creating an osmotic gradient that shifts water into the intravascular space. The combination is often studied in the context of optimizing fluid resuscitation strategies to improve hemodynamic stability and reduce complications like tissue edema.

Other names

crystalloid fluid combinationisotonic saline + hypertonic saline + ringer lactate