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ispaghula husk + lactobacillus acidophilus + lactobacillus plantarum + lactobacillus rhamnosus + bifidobacterium breve + bifidobacterium longum
- Development stage
- Unknown
- Lead developer
- Giuliani
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
This drug is a synbiotic combination product developed by the Italian company Nathura Srl, specifically designed for the treatment of functional and chronic constipation. It integrates a prebiotic component, ispaghula husk (psyllium), with a multi-strain probiotic consortium comprising *Lactobacillus acidophilus*, *Lactobacillus plantarum*, *Lactobacillus rhamnosus*, *Bifidobacterium breve*, and *Bifidobacterium longum*. The ispaghula husk acts as a bulk-forming agent that absorbs water, increasing stool volume and promoting peristalsis, while the probiotic strains work to restore and modulate the gut microbiota. Clinical evaluation, including Phase 4 randomized controlled trials, has demonstrated its efficacy in reducing intestinal transit time and improving stool consistency and frequency in adults meeting Rome III criteria for constipation.
- Brand names
- Psyllogel Megafermenti 24Psyllogel Megafermenti
- Other names
- psyllium + probioticssynbiotic mixture of ispaghula husk and probiotic Lactobacillus/Bifidobacterium strains
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