itopride + polyethylene glycol

This is a combination therapy consisting of itopride and polyethylene glycol, primarily used for bowel preparation prior to colonoscopy. Itopride is a prokinetic agent that acts as both a dopamine D2 receptor antagonist and an acetylcholinesterase inhibitor, thereby increasing gastrointestinal motility by enhancing acetylcholine activity in the gut[9][5]. Polyethylene glycol (PEG) is an osmotic laxative that retains water in the stool, resulting in softer stools and increased bowel movements; it is widely used for bowel cleansing before procedures such as colonoscopy[3][8]. The combination aims to improve the efficacy of bowel cleansing by leveraging PEG’s laxative effect with itopride’s ability to promote colonic peristalsis and reduce colonic fluid, potentially leading to better patient tolerance and more effective preparation outcomes[1][6].