ixazomib + pegylated liposomal doxorubicin + dexamethasone

This is a combination regimen consisting of **ixazomib**, an oral small molecule proteasome inhibitor; **pegylated liposomal doxorubicin** (PLD), a cytotoxic anthracycline antibiotic encapsulated in a liposomal carrier to reduce cardiotoxicity; and **dexamethasone**, a synthetic glucocorticoid corticosteroid. Ixazomib inhibits the chymotrypsin-like activity of the 20S proteasome, blocking protein degradation and inducing apoptosis in myeloma cells[5][1]. Pegylated liposomal doxorubicin intercalates DNA, inhibits topoisomerase II, and generates cytotoxic free radicals. Dexamethasone has anti-inflammatory, antiemetic, immunosuppressive, and direct antitumor activity in certain hematologic malignancies, acting via the glucocorticoid receptor[6]. This triple drug regimen is primarily used in the treatment of **relapsed or refractory multiple myeloma** and is being investigated in clinical trials for this indication. The combination leverages the targeted cytotoxic effects of ixazomib and doxorubicin with the immunomodulatory and supportive effects of dexamethasone.

Brand names

Doxil

Other names

ixazomib citratePLDadriamycin (liposomal)DXM