Drug intelligence / Profile preview

jasminum + calcium hydroxide

Development stage
Unknown
Lead developer
Shaheed Zulfiqar Ali Bhutto Medical University
Modality
Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Topical, Dental
01

Overview

jasminum + calcium hydroxide refers to a combination medicament, most notably a novel endodontic formulation developed for root canal therapy. This combination typically involves calcium hydroxide (Ca(OH)2) reinforced with titanium dioxide (TiO2) nanoparticles that are synthesized using a "green synthesis" method involving extracts from the *Jasminum* genus (such as *Jasminum sambac*). The formulation is designed to improve upon conventional calcium hydroxide treatments by enhancing antimicrobial efficacy and reducing postoperative pain in patients with symptomatic apical periodontitis. The calcium hydroxide component provides a high-pH environment (approximately 12.5) that is bactericidal and promotes the mineralization of periapical tissues. The *Jasminum*-derived nanoparticles and bioactive plant compounds (such as flavonoids and secoiridoids) provide additional anti-inflammatory and analgesic effects by modulating inflammatory mediators. Beyond dentistry, traditional and experimental uses of *Jasminum* juice mixed with calcium hydroxide (slaked lime) have been explored for the treatment of cutaneous wounds and skin conditions due to their synergistic regenerative and antiseptic properties.

Other names
Jasminum-based nano-reinforced calcium hydroxideJasmine-reinforced calcium hydroxide intracanal medicamentJasmine and lime mixtureJasminum sambac and calcium hydroxide paste
02

Targets

ALPL (Tissue-nonspecific alkaline phosphatase)TNFA (Tumor necrosis factor alpha (soluble))

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