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JCAR017 + CC-99282
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Small Molecules
- Administration
- Intravenous (JCAR017), Oral (CC-99282)
01
Overview
JCAR017 + CC-99282 is an investigational combination therapy for relapsed or refractory B-cell malignancies, notably including various forms of non-Hodgkin lymphoma. **JCAR017 (lisocabtagene maraleucel)** is a CD19-directed, autologous, genetically modified chimeric antigen receptor (CAR) T cell therapy. It reprograms the patient's own T cells to target and kill CD19-expressing B cells, a hallmark of many lymphomas. **CC-99282** is an oral CELMoD (cereblon E3 ligase modulator) small molecule designed to degrade Ikaros and Aiolos proteins, key transcription factors in B-cell malignancy survival, thereby enhancing T-cell and NK-cell mediated cytotoxicity. The combination is being evaluated to determine safety, tolerability, and effectiveness in B-cell lymphomas[1][3][4][6].
- Brand names
- Breyanzi (for JCAR017)
- Other names
- lisocabtagene maraleucel + CC-99282
02
Targets
IKZF3 (Zinc finger protein Aiolos)CD19 (B lymphocyte antigen CD19)CRBN (Cereblon)IKZF1 (Ikaros family zinc finger protein 1)ZFP91 (Zinc finger protein 91)
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