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jetPEI + miR-122
- Development stage
- Preclinical
- Modality
- Gene Therapies, Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intraperitoneal Injection
01
Overview
**jetPEI + miR-122** is a combination drug used for delivering miR-122, a microRNA that plays a role in regulating cell proliferation, migration, and apoptosis. **miR-122** is known to be downregulated in colon cancer cells, and its overexpression can enhance the expression of pro-apoptotic genes and reduce the expression of anti-apoptotic genes, thereby potentially inhibiting cancer progression[1][2]. **jetPEI** is a transfection reagent used for the efficient delivery of nucleic acids into cells, including microRNAs like miR-122.
02
Targets
MTDH (Metadherin)BAX (Apoptosis regulator BAX)CASP3 (Caspase-3)CASP9 (Caspase-9)IL-6 (Interleukin 6)VEGFA (Vascular endothelial growth factor A)
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