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Jiangxi Science & Technology Normal Univ. ALK compound Ld-10
- Development stage
- Preclinical
- Lead developer
- Jiangxi Science and Technology Normal University
- Modality
- Small Molecules
01
Overview
Jiangxi Science & Technology Normal Univ. ALK compound Ld-10: sourced facts only. name: "Among them, Ld-10 showed significant inhibitory activity against ALK kinase with an IC50 value of 1135 nM and demonstrated excellent antiproliferative activity against lung cancer cells H2228 with an IC50 value of 1.35 ± 0.13 μM." [PMID:40209355]; target: "Among them, Ld-10 showed significant inhibitory activity against ALK kinase with an IC50 value of 1135 nM and demonstrated excellent antiproliferative activity against lung cancer cells H2228 with an IC50 value of 1.35 ± 0.13 μM." [PMID:40209355]; developer: "Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, 330013, China." [PMID:40209355]; modality: "We designed and synthesized 48 novel 2,4-diarylpyrimidine-based ALK inhibitors and investigated their antitumor activities." [PMID:40209355]; stage: "Among them, Ld-10 showed significant inhibitory activity against ALK kinase with an IC50 value of 1135 nM and demonstrated excellent antiproliferative activity against lung cancer cells H2228 with an IC50 value of 1.35 ± 0.13 μM." [PMID:40209355]
02
Targets
ALK (Anaplastic lymphoma kinase receptor tyrosine kinase)
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