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JNJ-74856665 + azacitidine
- Development stage
- Unknown
- Lead developer
- Janssen Research & Development
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Subcutaneous
01
Overview
A combination of **JNJ-74856665**, an orally bioavailable, potent, and selective dihydroorotate dehydrogenase (DHODH) inhibitor, and **azacitidine**, a nucleoside metabolic inhibitor. JNJ-74856665 binds the enzyme’s ubiquinone-binding site, promoting differentiation of leukemic cells, cell cycle arrest, and apoptosis, while azacitidine inhibits DNA methyltransferase and is FDA-approved for certain myelodysplastic syndrome (MDS) subtypes. This combination is being developed as an investigational regimen for the treatment of hematological malignancies including acute myeloid leukemia (AML), MDS, and chronic myelomonocytic leukemia (CMML), and is currently under evaluation in early-phase clinical trials[2][3][4][5][7][6].
- Other names
- JNJ-6665 + azacitidineJNJ 74856665 + azacitidine
02
Targets
DHODH (Dihydroorotate dehydrogenase (quinone), mitochondrial)DNMT (DNA methyltransferase)
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