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Kanglaite + anlotinib
- Development stage
- Preclinical
- Lead developer
- Zhejiang Kanglaite Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Kanglaite + anlotinib is a combination therapy that pairs two anti-cancer agents with different mechanisms of action. Kanglaite (KLT) is a traditional Chinese medicine preparation derived from Coix seed oil, while anlotinib is a multi-targeted tyrosine kinase inhibitor. This combination is being investigated for the treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). The combination aims to leverage Kanglaite's ability to improve efficacy and reduce toxicity of conventional treatments alongside anlotinib's antiangiogenic and anti-tumor properties.
02
Targets
FGFR4 (Fibroblast growth factor receptor 4)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)FGFR3 (Fibroblast growth factor receptor 3)VEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)
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