ketamine + magnesium sulfate

Ketamine + magnesium sulfate is a drug combination that leverages the synergistic effects of both compounds on NMDA receptors. Ketamine is a non-competitive NMDA receptor antagonist, while magnesium sulfate is an endogenous voltage-dependent NMDA receptor-channel blocker[1][4]. This combination has been studied for various pain conditions, including neuropathic pain, postoperative pain, and refractory headaches[1][3]. The synergistic interaction occurs because ketamine and magnesium sulfate act on different sites of the NMDA receptor channel[1][4]. This combination may enhance analgesic efficacy while potentially allowing for reduced ketamine dosage, which could minimize adverse effects[1]. Studies have shown that the combination provides better pain control and reduces opioid consumption compared to ketamine alone in various surgical settings[2][7].