ketamine + midazolam + propofol

This entry refers to the comparative use of two sedation regimens—ketamine combined with midazolam versus ketamine combined with propofol—investigated by Alexandria University for procedural sedation in emergency department settings. Ketamine is a dissociative anesthetic that acts primarily as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. Midazolam is a benzodiazepine that functions as a positive allosteric modulator of the gamma-aminobutyric acid type A (GABA-A) receptor, providing anxiolysis and amnesia. Propofol is a short-acting intravenous anesthetic that also enhances GABA-A receptor activity to induce sedation. The combination of ketamine with either a benzodiazepine or propofol (often termed "ketofol") is intended to provide effective procedural sedation while minimizing the side effects associated with each agent used alone, such as respiratory depression, hypotension, or emergence delirium.

Other names

ketamine + midazolam + ketamine + propofol-Alexandria University-procedural sedationKetamine-Midazolam vs Ketamine-Propofol for Procedural Sedation in EDPropofol or Benzodiazepine Combined With Ketamine for Procedural Sedation in Emergency Setting