ketamine + morphine

Ketamine + morphine is a combination of two analgesic drugs used together primarily for the management of moderate to severe pain, especially in perioperative, emergency, and chronic pain settings. Ketamine is a rapid-acting dissociative anesthetic and N-methyl-D-aspartate (NMDA) receptor antagonist that provides analgesia by inhibiting excitatory neurotransmission involved in pain pathways. Morphine is an opioid agonist that acts mainly on mu-opioid receptors to produce potent analgesia. When combined, ketamine and morphine have been shown to provide synergistic or additive effects on pain relief, potentially reducing opioid requirements and attenuating the development of opioid tolerance. This combination may also be used when single-agent therapy is insufficient or when minimizing opioid dosage is desired due to side effect profiles[2][4][10].

Brand names

MKO Melt Dose PackMKH Dose Pack

Other names

PCA ketamine-morphineketamine-morphine combination