ketoconazole + zinc pyrithione

Ketoconazole + zinc pyrithione is a topical combination therapy developed by Biogracea Medicare for the treatment of fungal skin infections and scalp conditions such as seborrheic dermatitis and dandruff. Ketoconazole, an imidazole derivative, exerts its antifungal effect by inhibiting the enzyme lanosterol 14-alpha demethylase, which is critical for the biosynthesis of ergosterol in fungal cell membranes. Zinc pyrithione is a coordination complex that possesses both antifungal and antibacterial properties; it is thought to work by disrupting membrane transport and cellular metabolism, potentially through the regulation of intracellular metal ion concentrations. This synergistic combination is typically delivered in a shampoo or lotion base, providing both rapid symptomatic relief and long-term control of Malassezia-related conditions.

Brand names

KETO-Z

Other names

ketoconazole and zinc pyrithione