ketorolac + lidocaine + bupivacaine + hyaluronidase

This drug is a multi-component pharmaceutical mixture used as a peribulbar block for ophthalmic surgeries, specifically studied by **Cairo University** for managing postoperative pain. It consists of two local anesthetics, **lidocaine** and **bupivacaine**, which provide rapid-onset and long-acting regional anesthesia, respectively, by blocking voltage-gated sodium channels. **Hyaluronidase** is included as an enzymatic adjuvant to degrade hyaluronic acid in the extracellular matrix, thereby increasing tissue permeability and facilitating the spread of the anesthetic agents. **Ketorolac**, a non-steroidal anti-inflammatory drug (NSAID), is added to the mixture to enhance the quality of the block and provide prolonged postoperative analgesia by inhibiting prostaglandin synthesis through the inhibition of cyclooxygenase enzymes.

Other names

ketorolac + lidocaine + bupivacaine + hyaluronidase mixture