Drug intelligence / Profile preview

ketorolac + midazolam

Development stage
Preclinical
Lead developer
Roche
Modality
Small Molecules
Administration
Intravenous, Intramuscular
01

Overview

Ketorolac + midazolam is a combination used for sedation and pain management, particularly in surgical settings. This combination leverages the complementary effects of both medications: **Ketorolac** is a non-steroidal anti-inflammatory drug (NSAID) with potent analgesic, anti-inflammatory, and antipyretic properties. It works by blocking substances in the body that cause pain and inflammation. **Midazolam** is a short-acting benzodiazepine with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. When used together, this combination provides effective sedation and pain control while allowing patients to remain conscious during procedures. The combination has been studied in oral surgery and gynecologic procedures.

Other names
midazolam and ketorolacmidazolam/ketorolac
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)BZD site (GABA-A receptor benzodiazepine site)

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