ketorolac + prednisolone acetate

Ketorolac + prednisolone acetate is a fixed-dose combination of two ophthalmic agents used primarily for the treatment and prevention of inflammation and pain following ocular surgery, as well as for other inflammatory eye conditions. Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting prostaglandin synthesis through non-selective inhibition of cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing inflammation and pain[4][8]. Prednisolone acetate is a synthetic glucocorticoid corticosteroid that acts as an anti-inflammatory and immunosuppressive agent by binding to the glucocorticoid receptor, modulating gene expression, suppressing leukocyte infiltration at sites of inflammation, interfering with mediators of inflammatory response, and reducing edema[5]. The combination therapy offers additive or synergistic effects in controlling postoperative ocular inflammation compared to monotherapy[3].

Brand names

Acular + Pred ForteAcuvail + Pred ForteAcular LS + Pred Mild

Other names

ketorolac tromethamine + prednisolone acetate