ketotifen + acetylcysteine

A combination of the mast cell stabilizer ketotifen and the antioxidant N-acetylcysteine (NAC). This combination is utilized by Neurocentrx Pharma as a protective adjuvant system within their oral ketamine formulations, such as KET-AD. The combination is designed to mitigate the adverse effects associated with ketamine therapy, specifically ketamine-induced ulcerative cystitis (bladder inflammation) and oxidative stress, thereby allowing for safer long-term administration in patients with treatment-resistant bipolar depression. Ketotifen acts by stabilizing mast cells and antagonizing H1 receptors, while acetylcysteine serves as a precursor to glutathione, providing antioxidant protection to the bladder and central nervous system. This dual-action approach is intended to improve the tolerability and safety profile of oral ketamine.

Other names

ketotifen and N-acetylcysteine combination