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ketotifen + indomethacin
- Development stage
- Unknown
- Lead developer
- Sen-Jam Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ketotifen + indomethacin is a drug combination under investigation for the treatment of COVID-19. Ketotifen is an oral mast cell stabilizer used to prevent asthma and reduce vascular leakage, while indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and 2 receptors, reducing prostaglandin synthesis. The combination has shown additive or synergistic antiviral effects against SARS-CoV-2 in vitro, with increased inhibition of viral replication compared to either drug alone[1][2][3]. Clinical trials have evaluated its safety and efficacy for improving respiratory symptoms in COVID-19 patients.
- Brand names
- SJP-002CSJP002CSJP 002C
- Other names
- SARS CoV2 therapeutic
02
Targets
ABCC1 (MRP1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)mPGES-2 (Microsomal prostaglandin E synthase-2)Mast cell secretory machineryHRH1 (Histamine H1 Receptor)
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