ketotifen + naphazoline

Ketotifen + naphazoline is a fixed-dose combination ophthalmic drug used primarily for the symptomatic relief of allergic conjunctivitis and related ocular conditions. Ketotifen acts as a noncompetitive histamine H1 receptor antagonist and mast cell stabilizer, reducing allergic inflammation by blocking histamine-mediated symptoms and preventing the release of inflammatory mediators from mast cells. Naphazoline is an imidazoline-derived sympathomimetic vasoconstrictor that acts as an alpha adrenergic receptor agonist, leading to constriction of conjunctival blood vessels, thereby reducing eye redness and congestion. The combination provides both rapid relief from redness (via vasoconstriction) and longer-term control of itching (via antihistaminic/mast cell stabilization). It is typically administered as eye drops for short-term use in allergic or irritative conjunctivitis[1][3][4][5].

Other names

ketotifen + naphazoline