Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
KHK2866 + pegylated liposomal doxorubicin
- Development stage
- Discontinued
- Lead developer
- Kyowa Kirin
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
This is a **combination therapy** of **KHK2866**, a recombinant, humanized, non-fucosylated monoclonal antibody targeting **heparin-binding epidermal growth factor-like growth factor (HB-EGF)**, with **pegylated liposomal doxorubicin (PLD)**, an anthracycline chemotherapeutic encapsulated in liposomes and coated with polyethylene glycol. KHK2866 neutralizes HB-EGF activity by preventing its receptor binding, showing tumor-selective distribution. Pegylated liposomal doxorubicin inhibits topoisomerase 2, disrupting DNA replication in cancer cells and is designed for prolonged circulation and targeted tumor delivery. This combination was investigated for advanced cancers, particularly ovarian, fallopian tube, and primary peritoneal cancers[1][3][5].
- Other names
- PLDPegylated liposomal doxorubicin
02
Targets
DNAHBEGF (Heparin-binding EGF-like growth factor)TOP2A (DNA topoisomerase II)
Beyond the preview
Go deeper on KHK2866 + pegylated liposomal doxorubicin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on KHK2866 + pegylated liposomal doxorubicin.