Klean prep + Picoprep

Klean prep + Picoprep is a combination regimen used for bowel cleansing prior to colonoscopy or other gastrointestinal procedures. This regimen combines two different types of bowel preparation agents: - **Klean prep** contains polyethylene glycol (PEG), an osmotic laxative that works by retaining water in the stool, resulting in increased stool volume and promoting evacuation of the bowel. - **Picoprep** contains sodium picosulfate, magnesium oxide, and citric acid. Sodium picosulfate is a stimulant laxative that is converted by colonic bacteria into its active form to stimulate peristalsis. Magnesium oxide and citric acid react to form magnesium citrate, which acts as an osmotic laxative by drawing water into the intestines. The combination aims to maximize efficacy of bowel cleansing while improving patient tolerability compared with using either agent alone. Both components are well-established for use in colonoscopy preparation; studies show similar effectiveness between them individually but improved tolerability when regimens are tailored[4][6]. The primary indication is for pre-procedural bowel cleansing.

Brand names

Klean prep + Picoprep

Other names

PEG + SPMC