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KLH + peptides + dendritic cells
- Development stage
- Unknown
- Lead developer
- Leiden University Medical Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Peptides, Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous, Intravenous, Intranodal
01
Overview
KLH + peptides + dendritic cells is an investigational therapeutic cancer vaccine composed of autologous or donor-derived dendritic cells (DCs) that are ex vivo loaded (pulsed) with tumor-associated antigenic peptides and the carrier protein keyhole limpet hemocyanin (KLH). The combination is designed to induce a robust antigen-specific immune response by leveraging the potent antigen-presenting capacity of DCs. Peptides derived from tumor antigens are presented to T-cells to elicit cytotoxic responses against cancer cells, while co-loading with KLH serves as an immunogenic control and adjuvant, enhancing CD4+ T-cell priming and facilitating monitoring of immune responses. This approach has been studied in various cancers including melanoma, acute myeloid leukemia, and colorectal cancer[1][2][3][5]. The mechanism involves both cellular (T-cell mediated) and humoral (antibody-mediated) immunity.
- Other names
- KLH-loaded peptide-pulsed dendritic cell vaccineDC vaccine with KLH and peptidespeptide-pulsed DCs with KLH
02
Targets
γδ TCR (T-cell receptor)MHC II (Major histocompatibility complex class II receptor)HLA-B7
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