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KRAS (G12V) A*11 CAR-T
- Development stage
- Preclinical
- Lead developer
- MyriO Tx
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
KRAS (G12V) A*11 CAR-T is an investigational chimeric antigen receptor (CAR) T-cell therapy being developed by Myrio Therapeutics for the treatment of solid tumors harboring the KRAS G12V mutation, specifically in patients expressing the HLA-A*11 allele. The therapy involves engineering T cells to express a CAR that recognizes the KRAS G12V neoantigen peptide when presented by HLA-A*11 on the surface of tumor cells. This targeted approach aims to induce selective T-cell mediated lysis of cancer cells in indications such as lung, pancreatic, and colon cancers, while sparing healthy cells that do not present the specific mutation-HLA complex. The program is currently in the discovery stage of development.
- Other names
- KRAS G12V A*11 CAR-TMutant KRAS G12V CAR-T
02
Targets
KRASG12V (KRAS G12V)KRAS G12V/HLA-A*11:01 (KRAS G12V Mutant Peptide-HLA-A*11:01 Complex)
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