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KRAS (G12V) A*11 T Cell Engager
- Development stage
- Unknown
- Lead developer
- MyriO Tx
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
KRAS (G12V) A*11 T Cell Engager is a bispecific T-cell engager (BiTE) antibody being developed by Myrio Therapeutics. It is designed to target the KRAS G12V neoantigen presented by the HLA-A*11 major histocompatibility complex (MHC) on the surface of tumor cells. By simultaneously binding to this specific peptide-HLA complex and the CD3 receptor on T cells, the drug facilitates the recruitment and activation of T cells to selectively kill tumor cells expressing the KRAS G12V mutation. This therapeutic candidate is currently in the discovery phase for the treatment of KRAS G12V-mutated solid tumors, including lung, pancreatic, and colon cancers.
- Other names
- KRAS G12V A*11 T-cell engager
02
Targets
CD3 (T-cell surface glycoprotein CD3)KRAS G12V/HLA-A*11:01 (KRAS G12V Mutant Peptide-HLA-A*11:01 Complex)
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