Drug intelligence / Profile preview

l-carnitine + selenium

Development stage
Unknown
Lead developer
Lo.Li. Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

l-carnitine + selenium is a combination of two well-known antioxidant compounds often formulated together as a dietary supplement or medical food, particularly used in populations with increased oxidative stress such as phenylketonuria (PKU), osteoarthritis, thyroid diseases, and potentially other conditions involving oxidative imbalance. - **l-carnitine** acts primarily as a transporter of long-chain fatty acids into mitochondria for energy production and possesses direct antioxidant effects. - **selenium** is an essential trace mineral that serves as a cofactor for several antioxidant enzymes, notably glutathione peroxidase, which helps detoxify harmful peroxides in cells. Joint supplementation of l-carnitine and selenium has been shown to restore antioxidant capacity, reduce lipid and protein oxidative damage, and improve enzymatic antioxidant defense (such as glutathione peroxidase activity) in conditions associated with oxidative stress, e.g., PKU and thyroid dysfunction[1][3][5].

02

Targets

SLC25A20 (Carnitine/acylcarnitine translocase)GPX4 (Glutathione peroxidase 4)

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