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l-methylfolate + methylcobalamin + n-acetylcysteine
- Development stage
- Unknown
- Lead developer
- Pamlab
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This drug is a **combination oral prescription dietary supplement** containing **l-methylfolate (the active form of folate), methylcobalamin (an active form of vitamin B12), and n-acetylcysteine (NAC)**. It is used to meet increased nutritional needs for folate, vitamin B12, and as an antioxidant in certain populations. These nutrients act synergistically: l-methylfolate and methylcobalamin support methylation and homocysteine metabolism, while n-acetylcysteine acts as a free radical scavenger and glutathione precursor[1][2][3][7]. It is primarily indicated for dietary management of patients with suboptimal folate or B12 status, and for populations at risk for cognitive decline, including patients with memory loss, dementia, Alzheimer’s disease, or stroke[1][3][4][7]. It is not intended as a sole therapy for anemia.
- Brand names
- CerefolinNACMetafolbic PlusMetafolbic Plus RFL-Methyl-MC NAC
- Other names
- methylfolate + methylcobalamin + acetylcysteine
02
Targets
MTR (Methionine synthase)GSH (Glutathione synthesis / redox)DHFR (Dihydrofolate reductase)
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