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l-methylfolate + methylphenidate
- Development stage
- Unknown
- Lead developer
- Massachusetts General Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination of l-methylfolate and methylphenidate studied for the treatment of attention-deficit/hyperactivity disorder (ADHD). L-methylfolate is a form of folate that can cross the blood-brain barrier and is involved in the synthesis of neurotransmitters like dopamine and norepinephrine. Methylphenidate is a central nervous system stimulant commonly used to treat ADHD. The combination was investigated based on evidence that l-methylfolate augments antidepressant effects through catecholaminergic mechanisms that might also benefit ADHD treatment.
- Brand names
- DeplinConcerta
- Other names
- 5-MTHFlevomefolic acid6(S)-5-methyltetrahydrofolateOROS-MPHOROS-methylphenidate
02
Targets
SERT (Sodium-dependent serotonin transporter)DAT (Dopamine plasma membrane transport protein)NET (Norepinephrine Transporter)
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