Drug intelligence / Profile preview

l-theanine + passionflower extract + rhodiola extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a **combination dietary supplement** comprised of three primary botanical ingredients: **l-theanine**, an amino acid sourced from tea leaves; **passionflower extract** (usually standardized for flavonoids); and **rhodiola extract** (typically standardized for active constituents such as rosavins and salidrosides). - **L-theanine** exerts anxiolytic effects mainly by **stimulating the release of gamma-aminobutyric acid (GABA)**, a key inhibitory neurotransmitter, and modulating levels of serotonin and dopamine. - **Passionflower extract** is believed to act as a mild **monoamine oxidase (MAO) inhibitor**, helping sustain high GABA levels by reducing its breakdown and further promoting calm and relaxation[1][4]. - **Rhodiola extract** is an adaptogen that **improves the body's resistance to stress, reduces fatigue, and enhances mental clarity**[3][5]. This combination is mainly indicated for **stress reduction, anxiety relief, and mood support**. The three ingredients likely act **synergistically** on neurotransmitter pathways and stress adaptation mechanisms, although no pharmaceutical company markets this exact combination under a unique brand name. It is most commonly seen in multi-ingredient dietary supplements marketed for anxiety and stress management.

02

Targets

iGluR (Ionotropic receptor 76b (Ir76b))GABAA (Gamma-aminobutyric acid receptor)GABA-B (Gamma-aminobutyric acid receptor type B)

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