Drug intelligence / Profile preview

labetalol + glyceryl trinitrate

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Intravenous, Sublingual
01

Overview

A combination of labetalol, an alpha and beta adrenergic antagonist, and glyceryl trinitrate, a vasodilator. Labetalol blocks beta-1 receptors in the heart and alpha-1 receptors in blood vessels, while glyceryl trinitrate works by relaxing blood vessels. This combination is used primarily for managing hypertension and angina, though requires careful monitoring as it may cause excessive blood pressure reduction.

Other names
labetalol + nitroglycerin
02

Targets

ADRA1A (α1A)ADRB2 (β2)ADRB1 (β1)

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