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lacidophilin + vonoprazan
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics, Small Molecules
- Administration
- Oral
01
Overview
Lacidophilin + vonoprazan is an investigational combination regimen being evaluated for the first-line treatment of *Helicobacter pylori* infection. The regimen typically includes amoxicillin as part of a dual or triple therapy approach. Vonoprazan is a potassium-competitive acid blocker (PCAB) that inhibits the gastric H+/K+-ATPase, providing rapid and sustained acid suppression. Lacidophilin is a probiotic preparation containing *Lactobacillus acidophilus* used as an adjunct to modulate the gut microbiome, potentially increasing eradication rates and reducing the incidence of antibiotic-associated adverse effects. This combination is currently being studied in Phase 4 clinical trials in China.
- Other names
- lacidophilin + vonorazanlactobacillus acidophilus + vonoprazan
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)
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