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**Lactated Ringer's solution** is a sterile, isotonic balanced crystalloid for intravenous fluid and electrolyte replacement. Standard U.S. Lactated Ringer's Injection contains sodium chloride, sodium lactate, potassium chloride, and calcium chloride; typical electrolyte concentrations per liter are sodium 130 mEq, potassium 4 mEq, calcium 3 mEq, chloride approximately 109 to 110 mEq, and lactate 28 mEq. It expands extracellular and intravascular volume while replenishing electrolytes; metabolizable lactate provides an alkalinizing effect through conversion to bicarbonate. It is used for fluid resuscitation and treatment of dehydration, extracellular fluid losses, electrolyte depletion, and selected acid-base disturbances. The calcium-containing solution has important compatibility limitations, including avoidance of concomitant ceftriaxone administration in neonates. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3d29c8f-c326-4097-814a-7f4e08c67068))
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