Lactobacillus acidophilus + Lactobacillus bulgaricus + Streptococcus thermophilus + Bifidobacterium bifidum

This is a multi-strain probiotic complex developed by researchers at Cairo University for the prophylaxis of oral candidiasis, particularly in patients with Sjogren's syndrome. [1] The product is a biologic, administered as an oral capsule, containing the live microorganisms *Lactobacillus acidophilus*, *Lactobacillus bulgaricus*, *Streptococcus thermophilus*, and *Bifidobacterium bifidum*. [1] The therapeutic mechanism involves antagonizing *Candida* species in the oral cavity through multiple actions, including competition for mucosal binding sites, the production of antimicrobial compounds, and modulation of the host's local immune response. [1, 9] A Phase 1/2 randomized, double-blind, placebo-controlled trial (NCT03840538) involving Sjogren's syndrome patients demonstrated that a 5-week course of the probiotic capsules resulted in a statistically significant reduction in oral candidal load compared to placebo. [1] The research was published in *Rheumatology International* in 2020, though no specific brand name for the product has been identified. [1]

Other names

Probiotic Product-Cairo University-oral candidiasis